Evonik
Tuesday, November 03, 2020
10:00 a.m. EST / 4:00 p.m. CET

The development of extended release microparticles and nanoparticles with PLGA parenteral excipients

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Overview

Poly(lactide-co-glycolide) (PLG) parenteral excipients have been used for many decades with extended release microparticle, nanoparticle, implant and in-situ forming drug products due to their excellent bioabsorption and biocompatibility characteristics and long safety record.

This webinar will give an overview of key PLG proprieties relevant to drug delivery formulations including tunability. In addition, the relationship of PLG polymer properties, drug properties (peptides and small molecules) and product-by-process manufacturing will be discussed. Key areas of focus will be microencapsulation and precise hot melt extrusion manufacturing. Other topics to be covered will include mechanisms of drug release, the influence of drug content and product release testing.

Experts featuring this session

Dr. Thomas R. Tice
Senior Director Technical Global Technical Marketing
Evonik Health Care

Vita
Thomas Tice is internationally recognized for his research and product development of complex parenteral, drug delivery dosage forms based on bioabsorbable polymer excipients. He is known for his accomplishments involving injectable, extended-release microparticles made with bioabsorbable lactide/glycolide polymers designed for systemic and local drug delivery. He was a team leader and core inventor to develop the first commercial, injectable, extended-release microparticle product. This product, a one-month LHRH formulation indicated for the treatment of prostate cancer (Decapeptyl® SR), is still on the market today. He has also served on various US Pharmacopeia expert committees for 17 years, and is currently on the General Chapters Dosage Forms Expert Committee and Excipient Joint Committee.

At Evonik, Dr. Tice, provides scientific support to Evonik’s innovation, sales, product development, research, intellectual property and M&A teams. He earned his BSc in Chemistry and PhD in Biophysics from Syracuse University, New York. He held a postdoctoral fellow position at the University of Alabama at Birmingham (UAB) in Microbiology. He holds 48 US patents with many foreign equivalents and has more than 180 publications, presentations, and invited lectures to his credit. He flew experiments on two Space Shuttle flights.

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Details

Webinar language
English

Venue

Online

Questions?

Julia Born
Market Communications Health Care
+49 6151 18 4984 E-Mail
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