Purity is paramount – Customized approaches for superior quality control at Evonik

Overview

The quality of lipids in a lipid nanoparticle (LNP) assembly is critically important to the functionality of mRNA-based therapeutics. Any unwanted chemical reaction between the lipids and the labile mRNA will affect the product stability and efficacy of the vaccine or therapeutic.

In this webinar, our expert describes Evonik’s approach to superior quality control lipid analytics. In two case studies, this webinar outlines the role of novel multivariate models in speeding up timelines and increasing knowledge, and demonstrates that Evonik lipids show a consistently negligible level of N-oxide and aldehyde impurities, enabling safe usage in LNPs.

Key learnings for participants:

Lipid impurities and their impact on therapeutic effectiveness
Analytical assessment of N-Oxide and aldehyde impurities
Quality control best practice for lipid manufacturing

Experts featuring this session

Dr. Sabrina Metze
Head of QC Operations
Evonik Health Care
Vita

Sabrina Metze joined Evonik in 2019 as manager of analytical development projects for the Health Care business. In this role she was responsible for analytical development and transfer activities for customer and internal projects, from early development to commercial production. Since 2022, she has been head of QC operations.

Sabrina studied life sciences at Leibniz University in Hannover, Germany where she specialized in bioprocess engineering and the chemistry of natural compounds. She then completed a PhD, also in Hannover, on the scalability of single-use bioreactors using Process Analytical Technology (PAT) tools.

During her studies, and before starting at Evonik, she worked on several projects with the biotech company Sartorius Stedim Biotech.

Related webinars in this series

This is the third and last webinar of our three-part webinar series entitled "Lipids in Focus: Unleashing the Power of RNA Therapeutics".

To learn more about the two other webinars in this series please click on the respective webinar below. To register for multiple webinars of this series simply select them in the registration form.